All lanes were reopened around 3 p.m.
According to the Colorado State Patrol it happened just west of Tunnel One. The two cars involved in the crash came to a stop on ice in the Clear Creek.
A total of five people were injured in the crash. Two were critically hurt and two others suffered serious injuries.
Emergency crews were also trying to contain a fuel leak in the creek.
Troopers say the semi-truck was heading west on Highway 6 while three cars were heading east on Highway 6. At some point, the tanker truck swerved into the other lanes, colliding with the cars. Two of the cars ended up in Clear Creek.
No one has been cited in this wreck.
Officials say the semi-truck was carrying 6,000 gallons of asphalt oil which hardened as soon as it hit the ice in the creek forming sludge. The ice has helped in the cleanup because the oil solidified when it leaked out of the tank.
The closure extended from Highway 93 to Highway 119.
Pictures taken by 9NEWS reporter Brooke Thacker show one of the vehicles sitting on the frozen creek. The top of the car was removed by emergency crews to rescue the people inside.
The accident happened at 1:47 a.m. Wednesday.
According to officials, there are two people in critical condition, two people in serious condition and one with non-life-threatening injuries.
"Five people were transported to the hospital in total," Karlyn Tilley with the Golden Fire Department said. "But, there are no life-threatening injuries that we know of at this time. That's very lucky considering the severity of this crash."
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