The event kicked off Thursday and will also feature round-table discussions around the city on issues like poverty, health care and energy with current and former world leaders.
Art exhibits will be featured at the McNichols building in Civic Center Park, the Denver Botanic Gardens and the Denver Museum of Nature and Science.
The McNichols building has been transformed as the centerpiece of the event, draped in a pink, flowing canopy created by artist Jeronimo Hagerman of Mexico City.
"I was very interested in talking about the relationship this geographical point has with America and I dealt with it in a dreamlike way - our relationship with our dreams," Hagerman said.
He says he was inspired to bring in the feel of tropical colors and plants into the space.
Inside the McNichols building, an art exhibit called, "The Nature of Things" is being featured.
"When I first was here, it was all covered with sheet rock, I was wearing a hard hat, it was very, very different," Paola Santoscoy, curator of the exhibit, said. "It didn't look as great as it looks now. It's really changed."
The Mexico City native says now that the building has been transformed, there are a number of pieces of art worth coming to see before they are gone.
"There are many pieces that are site specific to the building and I think that's really something they should see," Santoscoy said. "It's only going to be here for one month."
Denver Mayor John Hickenlooper says he hopes the city will host the event every even-numbered year.
(KUSA-TV © 2010 Multimedia Holdings Corporation with The Associated Press)