The Colorado State Patrol says Julian Garcia of Denver was pronounced dead at the scene after the crash on North Washington Street one block north of 58th Avenue.
The driver of the car Garcia was in, 21-year-old Lilia Castilla, and two young boys, ages 2 and 10, were taken to Denver Health Medical Center. The extent of their injuries was not released.
Troopers say Castilla was heading north on Washington Street when she crashed her 1998 Dodge Avenger into the tractor-trailer.
The 10-year-old boy was thrown forward into Garcia.
State Patrol says the only one wearing a seat belt in the car was the 2-year-old boy.
The cause of the crash is still under investigation.
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