Forty-eight-year-old Ronald Herndon and 23-year-old Katrina Jaeger, both Greenwood Village residents, were pronounced dead at the scene.
The accident happened a little before 11 p.m. on S. Willow Way, just south of E. Orchard Road.
According to police investigators, the motorcycle was traveling northbound on S. Willow Way at a high rate of speed when the driver appeared to lose control of the motorcycle while trying to negotiate a right hand curve and ended up striking the median.
Police say both the driver of the motorcycle and his female passenger struck trees on the raised median of the roadway. Medical personnel were unable to revive either person.
The accident is under investigation.
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