Rescue crews used cranes to try and remove debris from the top of the building amid fears that machinery sifting through the wreckage could injure trapped survivors. Crowds of bystanders gathered as rescuers sifted through cement and glass.
The fatality at the Melcom Shopping Center at Achimota, a suburb of Accra, was confirmed by Public Affairs Officer of the Ghana Fire Service Billy Anaglate. "We are still working to find out the fate of others who may be trapped under," he said.
Other officials told The Associated Press that the death toll was likely to rise.
An AP reporter at the scene saw at least one man pulled from the debris, covered in dust and who was then whisked into an ambulance.
A Greater Accra Regional Public Affairs officer, deputy superintendent Freeman Tettey, confirmed that one person died and told the AP that 51 have been rescued and sent to hospitals around the capital.
"I was on my way to the shop when l saw it crumpling down," Kojo Boadi, an eyewitness, said.
President John Mahama declared the scene a disaster zone and cut short his election campaign in the north of the country to be able to visit the site. The presidential election is scheduled for December.
The five-story store opened in February is part of the Melcom chain owned by Indian immigrant magnate, Bhagwan Khubchandani. His late father arrived in Ghana in 1929 as a 14-year-old to work as a store boy in the-then Gold Coast.
The store sells a variety of cheap, imported household goods and appliances that are popular with working-class Ghanaians.
(Copyright 2012 by The Associated Press. All Rights Reserved.)