A few Libertarian-leaning Republicans are on board, too.
Legalization activists held a Capitol event Tuesday to promote the support of former Republican Rep. Tom Tancredo. Tancredo says he's never used marijuana but find its prohibition "nanny-state" interference.
"What is the law against marijuana if it isn't the nanny state telling you what you can and can't do?" Tancredo said during a Tuesday afternoon news conference at the Colorado State Capitol.
Republican Ken Buck, current District Attorney for Weld County, says he recently urged Tancredo to change his stance.
"I just think [Amendment 64] is a really bad idea," Buck said. "It would give Colorado a brand we just don't want to see. I want to make sure that Republicans understand that hurting kids is not a Republican value, and hurting business in Colorado is not a Republican value."
Also on hand were members of the Republican Liberty Caucus of Colorado, who back marijuana legalizations.
The conservatives cited states' rights while talking about marijuana. They also argued that youth access to the drug could be reduced and not expanded if marijuana were legal without a doctor's recommendation. That opinion is not shared by many in the Republican Party.
Colorado is one of three states considering ballot measures to legalize pot
(KUSA-TV © 2012 Multimedia Holdings Corporation with The Associated Press)