Eleven semi trucks and one SUV piled up about 17 miles west of Limon near Agate, according to the Colorado State Patrol.
One semi-truck caught fire with a form of adhesive inside. The semi smoldered for hours and burned to the ground.
Two people went to the hospital with minor injuries. The rest of the drivers and passengers walked away from the crash.
"Out of this crash, I'm very surprised there were so few injuries," Colorado State Patrol Trooper Josiah Ii said.
Both westbound lanes were reopened later in the evening.
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