Pierce Hornung had 13 points and seven rebounds while Dorian Green contributed 13 points and five assists for the Rams (7-2), who bounced back from losses to Colorado and Illinois-Chicago.
Colton Iverson had 10 points and Daniel Bejarano shared rebounding honors with seven. Colorado State was 7 for 11 from 3-point range and extended its seven-point halftime lead to as many as the final margin of 28.
Travis Wallace led the Ospreys (3-7) with 12 points. Parker Smith added 10 points.
The Rams owned a 41-23 rebounding edge and held North Florida to 43 percent shooting - 36 percent in the second half.
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