Kenyon Martin had 11 points and seven rebounds for the Nuggets, who had seven players score in double figures.

Corey Brewer led the Timberwolves with 23 points, Ryan Gomes had 16 and rookie Jonny Flynn scored 13.

Anthony, who played only 23 minutes against Minnesota, is averaging a point per minute in the preseason.

The Nuggets (3-3) used a big second quarter to pull away in their first preseason home game against an NBA team. Afflalo and Renaldo Balkman came off the bench in the period to score 10 points each, sparking Denver's 38-19 run that produced a 69-47 halftime lead.

Denver stretched its advantage to 97-74 heading into the fourth when rookie point guard Ty Lawson hit a running 45-foot bank shot at the buzzer.

The Timberwolves (1-5) played without center Al Jefferson, who is bothered by a sore Achilles' tendon. He sat out the fourth quarter of Saturday's game against Milwaukee.

Minnesota was also without big man Kevin Love, who will be sidelined 6-to-8 weeks due to a broken left hand.

The Nuggets trailed by nine midway through the first quarter before rallying to take a 28-26 on Anthony's three-point play. After Ryan Hollins tied it with a putback, J.R. Smith hit a 3-pointer with 0.3 seconds left in the quarter to give Denver the lead for good.

Denver's only other home preseason game was a 102-70 win over Partizan Belgrade on Oct. 3.